| Thu, 09/02/2010 | Cleveland Indians +139 at Seattle Mariners -154 | 7.5 |
| Fri, 09/03/2010 | Toronto Blue Jays +130 at New York Yankees -150 | Off |
| Fri, 09/03/2010 | New York Mets -110 at Chicago Cubs -110 | Off |
| Fri, 09/03/2010 | Milwaukee Brewers +230 at Philadelphia Phillies -270 | Off |
| Fri, 09/03/2010 | Tampa Bay Rays -200 at Baltimore Orioles +170 | Off |
| Fri, 09/03/2010 | Washington Nationals -117 at Pittsburgh Pirates -103 | Off |
| Fri, 09/03/2010 | Atlanta Braves -115 at Florida Marlins -105 | Off |
| Fri, 09/03/2010 | Chicago White Sox +135 at Boston Red Sox -155 | Off |
| Fri, 09/03/2010 | Detroit Tigers +138 at Kansas City Royals -158 | Off |
| Fri, 09/03/2010 | Texas Rangers +105 at Minnesota Twins -125 | Off |
| Fri, 09/03/2010 | Cincinnati Reds +115 at St. Louis Cardinals -135 | Off |
| Fri, 09/03/2010 | Houston Astros +130 at Arizona Diamondbacks -150 | Off |
| Fri, 09/03/2010 | Colorado Rockies +108 at San Diego Padres -128 | Off |
| Fri, 09/03/2010 | Los Angeles Angels +160 at Oakland Athletics -180 | Off |
| Fri, 09/03/2010 | Cleveland Indians -110 at Seattle Mariners -110 | Off |
| Fri, 09/03/2010 | San Francisco Giants +115 at Los Angeles Dodgers -135 | Off |
